MRPL51

Across TCGA patient cohorts, MRPL51 mutation is significantly associated with the RNA expression of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPL51-associated genes across cancer lineages are MIR6130, RN7SL301P, and ELMO2P1. Each is linked with MRPL51 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL51-to-partner and partner-to-MRPL51 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6130 grouped by MRPL51-low versus MRPL51-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL51→partner) and Y-score (partner→MRPL51) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR6130 →	+0.268	+7.471	<.001	.008	3	1
UCEC	RN7SL301P →	+0.257	+4.224	<.001	.001	3	1
UCEC	ELMO2P1 →	+0.181	+4.169	.007	.002	3	1
BRCA	RNU6-1299P →	+0.313	+5.721	.002	.003	3	1
BRCA	RNA5SP271 →	+0.707	+5.148	<.001	.008	3	1
BRCA	MIR3935 →	+0.313	+6.711	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

MIR6130 by MRPL51 expression — BRCA

Explore this box plot interactively →