MRPL51

Across TCGA pan-cancer cohorts, MRPL51 RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated MRPL51 data layer compared with 4 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher MRPL51 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MRPL51 expression acts as an unfavorable survival marker, although some lineages such as LUSC and OV show a favorable association.

UVM, ACC, and MESO are the cancer types where MRPL51 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.308	0.667	<.001	107	view →
ACC	OS	Tertile	All	0.314	0.725	<.001	86	view →
MESO	OS	Tertile	All	0.385	0.680	<.001	57	view →
LUSC	OS	Tertile	All	0.823	0.710	.003	43	view →
LUAD	DFS	Median	All	0.261	0.432	<.001	38	view →
LIHC	OS	Tertile	All	0.679	0.828	.001	36	view →
LGG	DFS	Tertile	All	0.652	0.797	.001	24	view →
KIRC	OS	Median	II,III,IV	0.723	0.879	<.001	24	view →
SKCM	DFS	Tertile	All	0.662	0.859	.004	22	view →
OV	DFS	Quartile	IV	0.627	0.301	.007	20	view →
UCS	OS	Median	IV	0.404	0.752	.013	18	view →
KICH	DFS	Median	III,IV	0.374	0.901	.009	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

MRPL51–UVM (DFS)

Open the UVM breakdown →