MRPL49

Across TCGA pan-cancer cohorts, MRPL49 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated MRPL49 data layer compared with 22 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher MRPL49 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated MRPL49 expression acts as an unfavorable survival marker, although some lineages such as PDAC and COAD show a favorable association.

PDAC, COAD, and GBM are the cancer types where MRPL49 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	II,III,IV	0.909	0.775	.004	31	view →
COAD	DFS	Quartile	All	1.000	0.861	.023	18	view →
GBM	OS	Tertile	All	0.632	0.401	.017	7	view →
HNSC	OS	Quartile	All	0.723	0.880	.016	7	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	3	view →
LSCC	DFS	Median	II,III,IV	0.817	0.555	.030	2	view →
CCRCC	DFS	Median	II,III,IV	0.602	0.809	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

MRPL49–PDAC (OS)

Open the PDAC breakdown →