MRPL49

Across TCGA pan-cancer cohorts, MRPL49 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of MRPL49’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where MRPL49 RNA is repressed in tumor relative to normal tissue. In most cancer types MRPL49 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, BLCA, and LIHC are the cancer types where MRPL49 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MRPL49 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.711	<.001	10	view →
BLCA	All	All	+0.466	<.001	10	view →
LIHC	Male	All	+0.889	<.001	9	view →
HNSC	All	All	+0.464	<.001	9	view →
KICH	Female	All	−0.899	<.001	7	view →
KIRC	Male	II,III,IV	−0.580	<.001	7	view →
BRCA	All	III,IV	+0.666	<.001	6	view →
KIRP	Male	All	−0.620	<.001	6	view →
COAD	All	II,III,IV	+0.379	<.001	6	view →
STAD	All	II,III,IV	+0.533	<.001	4	view →
CHOL	All	All	+0.948	<.001	3	view →
LUAD	Male	All	+0.328	.014	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

MRPL49–THCA

Open the THCA breakdown →