Across TCGA patient cohorts, MRPL42 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPL42-associated genes across cancer lineages are A-Raf_pS299, Gab2, and JNK2. Each is linked with MRPL42 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL42-to-partner and partner-to-MRPL42 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL42→partner) and Y-score (partner→MRPL42) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.158	-3.000	.011	.036	3	1
UCEC	Gab2 →	+0.464	+3.321	.013	.010	3	1
UCEC	JNK2 →	+0.238	+3.321	.022	.010	3	1
UCEC	p70-S6K_pT389 →	-0.270	-3.160	.006	.019	3	1
UCEC	Syk →	+0.391	+2.183	.046	.035	3	1
UCEC	Tuberin_pT1462 →	+0.299	+3.321	.013	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

MRPL42 survival (RNA) · tumor vs normal (RNA) · all MRPL42 data types