Across TCGA pan-cancer cohorts, MRPL42 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of MRPL42’s most consistent transcriptional readouts.
The strongest signal is observed in bladder urothelial carcinoma (BLCA), where MRPL42 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MRPL42 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.
BLCA, LIHC, and HNSC are the cancer types where MRPL42 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MRPL42 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.