MRPL34

Across TCGA pan-cancer cohorts, MRPL34 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated MRPL34 data layer compared with 25 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher MRPL34 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MRPL34 expression acts as an unfavorable survival marker, although some lineages such as COAD and PDAC show a favorable association.

COAD, PDAC, and LUAD are the cancer types where MRPL34 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	II,III,IV	1.000	0.877	.017	78	view →
PDAC	OS	Median	III,IV	1.000	0.537	.013	21	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	14	view →
LSCC	DFS	Quartile	II,III,IV	0.248	1.000	.038	3	view →
HNSC	OS	Median	II,III,IV	0.802	0.639	.030	3	view →
CCRCC	OS	Quartile	II,III,IV	0.839	0.563	.026	2	view →
GBM	DFS	Quartile	All	0.883	0.558	.041	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

MRPL34–COAD (DFS)

Open the COAD breakdown →