MRPL34

Across TCGA pan-cancer cohorts, MRPL34 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of MRPL34’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MRPL34 RNA is repressed in tumor relative to normal tissue. In most cancer types MRPL34 is over-expressed in tumor, although a few such as KIRC and LUAD show the opposite, repressed pattern.

KIRC, LUAD, and KIRP are the cancer types where MRPL34 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MRPL34 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−0.724	<.001	11	view →
LUAD	All	All	−0.317	.002	5	view →
KIRP	Male	All	−0.551	<.001	4	view →
THCA	Male	II,III,IV	−0.526	.004	4	view →
BRCA	All	All	+0.147	.016	4	view →
ESCA	Male	All	+0.596	.004	2	view →
UCEC	All	III,IV	+0.443	.028	2	view →
BLCA	All	All	+0.396	.024	2	view →
LUSC	All	II,III,IV	+0.375	.014	2	view →
HNSC	Male	III,IV	+0.353	.033	2	view →
PRAD	All	All	−0.257	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

MRPL34–KIRC

Open the KIRC breakdown →