MRPL34

Across TCGA patient cohorts, MRPL34 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPL34-associated genes across cancer lineages are RNA5SP463, RNU4-7P, and RNU6-1005P. Each is linked with MRPL34 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL34-to-partner and partner-to-MRPL34 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP463 grouped by MRPL34-low versus MRPL34-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL34→partner) and Y-score (partner→MRPL34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP463 →	+0.612	+4.258	.007	.003	3	1
UCEC	RNU4-7P →	+0.373	+4.538	<.001	.006	3	1
UCEC	RNU6-1005P →	+0.830	+4.258	.001	.003	3	1
UCEC	KRTAP3-3 →	+1.378	+3.911	<.001	.007	3	1
UCEC	RPL36P18 →	+0.367	+4.221	.003	.003	3	1
UCEC	RNU6-299P →	+0.395	+4.997	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

RNA5SP463 by MRPL34 expression — UCEC

Explore this box plot interactively →