MRPL32

Across TCGA patient cohorts, MRPL32 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPL32-associated genes across cancer lineages are Shc_pY317, JNK_pT183_Y185, and p70-S6K. Each is linked with MRPL32 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL32-to-partner and partner-to-MRPL32 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by MRPL32-low versus MRPL32-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL32→partner) and Y-score (partner→MRPL32) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.195	-3.321	.005	.010	3	2
UCEC	JNK_pT183_Y185 →	-0.199	-3.169	.011	.019	3	1
UCEC	p70-S6K →	+0.189	+2.611	.035	.006	3	1
UCEC	PDCD4 →	-0.590	-2.999	.007	.035	3	1
UCEC	VHL →	-0.904	-2.321	.004	.034	3	1
UCEC	JNK2 →	+0.202	+2.584	.029	.011	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Shc_pY317 by MRPL32 expression — UCEC

Explore this box plot interactively →