MRPL32

Across TCGA pan-cancer cohorts, MRPL32 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated MRPL32 data layer compared with 3 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MRPL32 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MRPL32 expression acts as an unfavorable survival marker, although some lineages such as KIRC and THCA show a favorable association.

HNSC, LGG, and LUAD are the cancer types where MRPL32 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.619	0.751	<.001	73	view →
LGG	OS	Median	All	0.721	0.890	<.001	54	view →
LUAD	OS	Tertile	All	0.239	0.457	.003	51	view →
UVM	DFS	Quartile	All	0.276	0.737	.002	49	view →
KIRC	DFS	Median	All	0.738	0.501	<.001	44	view →
KICH	DFS	Quartile	II,III,IV	0.534	1.000	.003	40	view →
SCLC	OS	Median	II,III,IV	0.501	1.000	.012	15	view →
CESC	OS	Tertile	III,IV	0.575	0.849	.029	14	view →
PAAD	DFS	Tertile	All	0.398	0.693	.002	13	view →
LIHC	OS	Quartile	All	0.595	0.760	.010	13	view →
READ	OS	Tertile	IV	0.526	0.913	.011	9	view →
GBM	OS	Tertile	All	0.324	0.501	.018	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

MRPL32–HNSC (DFS)

Open the HNSC breakdown →