MRPL24

Across TCGA pan-cancer cohorts, MRPL24 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MRPL24 data layer compared with 25 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MRPL24 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MRPL24 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where MRPL24 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.690	0.868	.005	20	view →
CCRCC	DFS	Tertile	III,IV	0.220	0.739	.001	19	view →
PDAC	DFS	Tertile	II,III,IV	0.490	0.283	.009	9	view →
LUAD	DFS	Median	III,IV	0.409	0.941	.010	6	view →
LSCC	OS	Quartile	II,III,IV	1.000	0.714	.015	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MRPL24–HNSC (DFS)

Open the HNSC breakdown →