MRPL19

Across TCGA patient cohorts, MRPL19 mutation is significantly associated with the RNA expression of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPL19-associated genes across cancer lineages are RNU6-830P, RNU6-627P, and RN7SL275P. Each is linked with MRPL19 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL19-to-partner and partner-to-MRPL19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-830P grouped by MRPL19-low versus MRPL19-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL19→partner) and Y-score (partner→MRPL19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-830P →	+0.228	+7.816	<.001	.008	3	1
LUAD	RNU6-627P →	+0.398	+7.930	<.001	.008	3	1
UCEC	RN7SL275P →	+0.177	+3.666	<.001	.004	3	1
UCEC	IGKV3OR2-5 →	+0.837	+4.050	.002	.001	3	1
UCEC	PRORY →	+0.055	+5.148	<.001	.002	3	1
UCEC	RNA5SP507 →	+0.492	+3.355	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

RNU6-830P by MRPL19 expression — SKCM

Explore this box plot interactively →