MROH1

Across TCGA pan-cancer cohorts, MROH1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of MROH1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where MROH1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types MROH1 is over-expressed in tumor, although a few such as LSCC and PDAC show the opposite, repressed pattern.

LSCC, PDAC, and LUAD are the cancer types where MROH1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MROH1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Female	II,III,IV	−0.451	<.001	8	view →
PDAC	All	All	−0.243	<.001	5	view →
LUAD	Female	All	+0.221	.001	5	view →
CCRCC	All	All	−0.080	.030	2	view →
COAD	Male	III,IV	+0.252	.008	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

MROH1–LSCC

Open the LSCC breakdown →