MROH1

Across TCGA pan-cancer cohorts, MROH1 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated MROH1 data layer compared with 10 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher MROH1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MROH1 expression acts as an unfavorable survival marker, although some lineages such as SCLC and KIRP show a favorable association.

UVM, CESC, and KIRC are the cancer types where MROH1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.421	0.781	<.001	123	view →
CESC	DFS	Median	II,III,IV	0.574	0.842	<.001	94	view →
KIRC	DFS	Quartile	IV	0.313	0.727	.004	63	view →
SCLC	DFS	Median	All	0.742	0.495	.001	42	view →
KICH	OS	Tertile	III,IV	0.169	0.913	.004	36	view →
LUSC	DFS	Quartile	All	0.238	0.436	.003	32	view →
KIRP	OS	Quartile	II,III,IV	0.863	0.505	.003	30	view →
LGG	DFS	Median	All	0.744	0.896	<.001	29	view →
COAD	DFS	Median	IV	0.287	0.642	.016	12	view →
OV	DFS	Median	IV	0.361	0.550	.012	12	view →
LUAD	DFS	Tertile	IV	0.201	0.824	.006	12	view →
PRAD	DFS	Tertile	All	0.757	0.891	.010	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

MROH1–UVM (OS)

Open the UVM breakdown →