MROH1

Across TCGA patient cohorts, MROH1 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. STAD shows the largest number of these associations.

The most reproducible MROH1-associated genes across cancer lineages are mTOR, p62 Lck ligand, and TIGAR. Each is linked with MROH1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MROH1-to-partner and partner-to-MROH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR grouped by MROH1-low versus MROH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MROH1→partner) and Y-score (partner→MROH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR →	-0.102	-1.222	.026	.011	3	3
UCEC	p62 Lck ligand →	+0.292	+1.398	.001	.004	3	3
UCEC	TIGAR →	+0.096	+1.611	.027	<.001	3	3
UCEC	ATM →	-0.409	-2.234	.001	.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.553	+1.382	.001	.021	3	3
STAD	LKB1 →	-0.102	-2.321	.036	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

mTOR by MROH1 expression — UCEC

Explore this box plot interactively →