MROH1

Across TCGA cell cohorts, MROH1 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible MROH1-associated genes across cancer lineages are LEUTX, LRIT1, and OR1L6. Each is linked with MROH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MROH1-to-partner and partner-to-MROH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LEUTX grouped by MROH1-low versus MROH1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MROH1→partner) and Y-score (partner→MROH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	LEUTX →	+0.050	+5.266	<.001	.001	3	2
STOMACH	LRIT1 →	+0.026	+3.017	.003	.001	3	2
LUNG_NSCLC_LUAD	OR1L6 →	+0.014	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR13C8 →	+0.024	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	KRTAP19-5 →	+0.429	+4.212	<.001	.007	3	1
LUNG_NSCLC_LUAD	PRAMEF20 →	+0.017	+4.662	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

LEUTX by MROH1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →