MROH1

Across TCGA cell cohorts, MROH1 mutation is significantly associated with the mutation status of many other genes, with 2,223 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MROH1-associated genes across cancer lineages are ITGB4, CDHR5, and RIMS1. Each is linked with MROH1 in more than 3 cancer types. Because this analysis shows association rather than direction, both MROH1-to-partner and partner-to-MROH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ITGB4 grouped by MROH1-low versus MROH1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MROH1→partner) and Y-score (partner→MROH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ITGB4 →	+3.584	+4.922	.001	.001	1	4
BLOOD_Leukemia	CDHR5 →	+2.975	+4.741	<.001	<.001	1	4
LUNG_NSCLC_LUAD	RIMS1 →	+3.000	+3.662	.007	.007	1	3
LUNG_NSCLC_LUAD	TMPRSS11B →	+5.000	+4.187	.008	.008	1	3
SKIN	EEA1 →	+4.824	+5.392	.004	.004	1	3
SKIN	USP31 →	+4.824	+5.392	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,223 associations by consensus.

ITGB4 by MROH1 expression — BLOOD_Lymphoma

Explore this box plot interactively →