MRO

Across TCGA patient cohorts, MRO mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRO-associated genes across cancer lineages are EGFR_pY1068, PDCD4, and c-Met_pY1235. Each is linked with MRO in more than 1 cancer types. Because this analysis shows association rather than direction, both MRO-to-partner and partner-to-MRO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by MRO-low versus MRO-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRO→partner) and Y-score (partner→MRO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.353	-3.247	<.001	<.001	3	2
UCEC	PDCD4 →	-0.666	-3.584	<.001	.002	3	2
UCEC	c-Met_pY1235 →	+0.072	+2.009	.011	.017	3	2
SKCM	MIG-6 →	+0.237	+2.832	.002	.034	3	1
SKCM	TAZ →	+0.237	+2.321	.002	.035	3	1
UCEC	eEF2 →	+0.349	+3.169	.010	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

EGFR_pY1068 by MRO expression — UCEC

Explore this box plot interactively →