MRO

Across TCGA pan-cancer cohorts, MRO RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of MRO’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MRO RNA is repressed in tumor relative to normal tissue. In most cancer types MRO is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and KIRP are the cancer types where MRO tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MRO RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	−1.829	<.001	12	view →
THCA	Male	IV	−4.006	<.001	11	view →
KIRP	All	II,III,IV	−2.982	<.001	11	view →
KICH	Male	II,III,IV	−2.853	<.001	10	view →
LIHC	Female	All	−0.932	<.001	8	view →
BRCA	All	All	−0.328	<.001	6	view →
CHOL	Male	All	−1.316	<.001	5	view →
BLCA	Male	All	−0.314	.008	5	view →
LUAD	All	All	+0.285	<.001	3	view →
PRAD	All	All	−0.723	<.001	2	view →
HNSC	Male	All	−0.267	.010	2	view →
READ	Female	All	−0.244	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

MRO–KIRC

Open the KIRC breakdown →