MRO

Across TCGA cell cohorts, MRO RNA expression is significantly associated with the go_rna of many other GO terms, with 2,432 significant associations in total. BONE shows the largest number of these associations.

The most reproducible MRO-associated GO terms across cancer lineages are Positive regulation of interleukin-8 production, Regulation of calcium ion transport into cytosol, and Positive regulation of glomerular filtration. Each is linked with MRO in more than 7 cancer types. Because this analysis shows association rather than direction, both MRO-to-partner and partner-to-MRO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of interleukin-8 production grouped by MRO-low versus MRO-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MRO→partner) and Y-score (partner→MRO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Positive regulation of interleukin-8 production →	-0.093	-0.686	<.001	<.001	3	8
SOFT_TISSUE	Regulation of calcium ion transport into cytosol →	-0.296	-0.361	<.001	<.001	3	7
BONE	Positive regulation of glomerular filtration →	-1.536	-1.100	<.001	.006	3	7
LUNG_NSCLC_LUAD	Sulfur compound metabolic process →	+0.040	+0.221	<.001	.008	3	7
BONE	Renal vesicle formation →	+1.061	+1.478	<.001	<.001	3	7
BONE	Metanephric renal vesicle formation →	+1.061	+1.478	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,432 associations by consensus.

Positive regulation of interleukin-8 production by MRO expression — SKIN

Explore this box plot interactively →