MRO

Across TCGA cell cohorts, MRO mutation is significantly associated with the mutation status of many other genes, with 220 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible MRO-associated genes across cancer lineages are CPS1, SARS1, and RETSAT. Each is linked with MRO in more than 1 cancer types. Because this analysis shows association rather than direction, both MRO-to-partner and partner-to-MRO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CPS1 grouped by MRO-low versus MRO-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRO→partner) and Y-score (partner→MRO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CPS1 →	+2.977	+4.392	.005	.005	1	1
SKIN	SARS1 →	+5.392	+4.824	.004	.004	1	1
SKIN	RETSAT →	+4.392	+4.392	.009	.009	1	1
SKIN	MPO →	+3.392	+4.718	.002	.002	1	1
SKIN	RIMBP2 →	+2.807	+4.247	.007	.007	1	1
SKIN	SEZ6 →	+4.392	+4.392	.009	.009	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 220 associations by consensus.

CPS1 by MRO expression — SKIN

Explore this box plot interactively →