Across TCGA cell cohorts, MRLN RNA expression is significantly associated with the go_rna of many other GO terms, with 2,016 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible MRLN-associated GO terms across cancer lineages are Negative regulation of calcium ion import into sarcoplasmic reticulum, Import across plasma membrane, and Gastro-intestinal system smooth muscle contraction. Each is linked with MRLN in more than 8 cancer types. Because this analysis shows association rather than direction, both MRLN-to-partner and partner-to-MRLN results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MRLN→partner) and Y-score (partner→MRLN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of calcium ion import into sarcoplasmic reticulum →	+1.370	+2.766	<.001	<.001	3	9
SOFT_TISSUE	Import across plasma membrane →	-0.043	-2.126	<.001	<.001	3	5
SOFT_TISSUE	Gastro-intestinal system smooth muscle contraction →	+0.748	+1.831	.002	<.001	3	4
BLOOD_Leukemia	Intracellular distribution of mitochondria →	+0.084	+0.178	.001	.001	3	4
SOFT_TISSUE	Positive regulation of retinoic acid receptor signaling pathway →	+0.156	+2.896	<.001	<.001	3	4
LARGE_INTESTINE	Amino acid metabolic process →	+0.040	+0.452	.003	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,016 associations by consensus.

Exploration

MRLN survival (RNA) · tumor vs normal (RNA) · all MRLN data types