Across TCGA pan-cancer cohorts, MRLN RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of MRLN’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where MRLN RNA is repressed in tumor relative to normal tissue. In most cancer types MRLN is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.
KIRP, KIRC, and KICH are the cancer types where MRLN tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MRLN RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.