MRGPRX6P

Across TCGA pan-cancer cohorts, MRGPRX6P RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated MRGPRX6P data layer.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher MRGPRX6P RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated MRGPRX6P expression acts as an unfavorable survival marker, although some lineages such as ESCA and STAD show a favorable association.

ESCA, KIRC, and READ are the cancer types where MRGPRX6P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	DFS	Tertile	III,IV	1.000	0.366	.005	81	view →
KIRC	DFS	Tertile	IV	0.121	0.625	<.001	72	view →
READ	DFS	Tertile	All	0.111	0.820	<.001	36	view →
LIHC	DFS	Tertile	All	0.020	0.554	<.001	36	view →
STAD	DFS	Tertile	III,IV	0.800	0.563	.023	24	view →
COAD	OS	Tertile	II,III,IV	0.465	0.787	.031	18	view →
BLCA	OS	Tertile	IV	0.133	0.589	.006	18	view →
LGG	DFS	Tertile	All	0.201	0.743	<.001	18	view →
SKCM	DFS	Tertile	All	1.000	0.621	.028	15	view →
THCA	DFS	Tertile	All	0.205	0.814	.035	9	view →
SARC	DFS	Tertile	All	0.200	0.597	.010	9	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

MRGPRX6P–ESCA (DFS)

Open the ESCA breakdown →