MRGPRX4

Across TCGA patient cohorts, MRGPRX4 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRGPRX4-associated genes across cancer lineages are EGFR_pY1173, Ku80, and Cyclin-E2. Each is linked with MRGPRX4 in more than 2 cancer types. Because this analysis shows association rather than direction, both MRGPRX4-to-partner and partner-to-MRGPRX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1173 grouped by MRGPRX4-low versus MRGPRX4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRGPRX4→partner) and Y-score (partner→MRGPRX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1173 →	+0.061	+1.348	.047	.045	3	3
SKCM	Ku80 →	+0.372	+3.169	.013	.019	3	2
UCEC	Cyclin-E2 →	+0.225	+3.817	<.001	<.001	3	2
UCEC	eIF4G →	+0.295	+1.678	.013	.023	3	1
UCEC	A-Raf_pS299 →	-0.121	-2.584	.008	.010	3	1
UCEC	HER3_pY1289 →	+0.065	+1.604	.049	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

EGFR_pY1173 by MRGPRX4 expression — UCEC

Explore this box plot interactively →