MRGPRX4

Across TCGA pan-cancer cohorts, MRGPRX4 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of MRGPRX4’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where MRGPRX4 RNA is repressed in tumor relative to normal tissue. In most cancer types MRGPRX4 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.

BRCA, LIHC, and LUAD are the cancer types where MRGPRX4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MRGPRX4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	Female	All	−0.104	<.001	6	view →
LIHC	All	All	+0.008	.008	3	view →
LUAD	Male	All	+0.031	.026	2	view →
HNSC	All	All	+0.086	.027	1	view →
LUSC	All	All	+0.057	.043	1	view →
KICH	All	All	+0.015	.023	1	view →
STAD	All	II,III,IV	+0.015	.049	1	view →
KIRC	Male	All	+0.005	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

MRGPRX4–BRCA

Open the BRCA breakdown →