MRGPRX4

Across TCGA cell cohorts, MRGPRX4 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MRGPRX4-associated genes across cancer lineages are KLK15, GDF5-AS1, and IFNA2. Each is linked with MRGPRX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRGPRX4-to-partner and partner-to-MRGPRX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLK15 grouped by MRGPRX4-low versus MRGPRX4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRGPRX4→partner) and Y-score (partner→MRGPRX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KLK15 →	+0.350	+4.091	<.001	.002	3	1
BLOOD_Leukemia	GDF5-AS1 →	+0.021	+4.481	<.001	.004	3	1
BREAST	IFNA2 →	+0.022	+5.169	<.001	.005	3	1
LARGE_INTESTINE	OR4A47 →	+0.030	+6.022	<.001	.001	3	1
LARGE_INTESTINE	USP17L20 →	+0.006	+4.977	<.001	.007	3	1
BLOOD_Leukemia	UNC45B →	+0.146	+3.408	<.001	.005	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

KLK15 by MRGPRX4 expression — BLOOD_Leukemia

Explore this box plot interactively →