MRGPRX3

Across TCGA patient cohorts, MRGPRX3 mutation is significantly associated with the RNA expression of many other genes, with 2,497 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRGPRX3-associated genes across cancer lineages are RNU6-1245P, TRAJ36, and RN7SL248P. Each is linked with MRGPRX3 in more than 2 cancer types. Because this analysis shows association rather than direction, both MRGPRX3-to-partner and partner-to-MRGPRX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1245P grouped by MRGPRX3-low versus MRGPRX3-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRGPRX3→partner) and Y-score (partner→MRGPRX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-1245P →	+0.430	+3.639	<.001	.006	3	3
COAD	TRAJ36 →	+0.582	+2.661	.002	.009	3	3
UCEC	RN7SL248P →	+0.051	+2.915	<.001	.007	3	3
UCEC	RRM2 →	+0.953	+2.321	<.001	.001	3	3
UCEC	UFD1 →	+0.379	+2.375	<.001	<.001	3	3
UCEC	TIPIN →	+0.388	+1.947	.005	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,497 associations by consensus.

RNU6-1245P by MRGPRX3 expression — HNSC

Explore this box plot interactively →