MRGPRF

Across TCGA pan-cancer cohorts, MRGPRF mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MRGPRF data layer compared with 23 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher MRGPRF mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated MRGPRF expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

LSCC, UCEC, and LUAD are the cancer types where MRGPRF mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	All	0.783	0.965	.005	27	view →
UCEC	OS	Median	III,IV	0.494	1.000	.016	12	view →
LUAD	DFS	Quartile	All	0.887	0.420	.001	11	view →
GBM	OS	Quartile	All	0.786	0.516	.031	3	view →
PDAC	DFS	Quartile	II,III,IV	0.780	1.000	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MRGPRF–LSCC (OS)

Open the LSCC breakdown →