MRGPRF-AS1

Across TCGA pan-cancer cohorts, MRGPRF-AS1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated MRGPRF-AS1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MRGPRF-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated MRGPRF-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and ESCA show a favorable association.

HNSC, ESCA, and LUAD are the cancer types where MRGPRF-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.454	0.259	<.001	143	view →
ESCA	DFS	Quartile	III,IV	0.670	0.256	<.001	28	view →
LUAD	DFS	Median	III,IV	0.659	0.329	.001	25	view →
STAD	DFS	Median	All	0.602	0.810	.003	22	view →
MESO	DFS	Quartile	All	0.189	0.732	.006	21	view →
THCA	OS	Tertile	II,III,IV	0.944	1.000	.003	15	view →
THYM	DFS	Quartile	II,III,IV	0.949	0.495	.007	15	view →
SARC	OS	Median	All	0.901	0.744	.004	14	view →
BRCA	OS	Quartile	III,IV	0.925	0.747	.001	12	view →
GBM	OS	Quartile	All	0.279	0.588	.002	9	view →
PAAD	DFS	Median	II,III,IV	0.522	0.392	.020	7	view →
KICH	DFS	Quartile	II,III,IV	0.474	0.893	.016	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

MRGPRF-AS1–HNSC (OS)

Open the HNSC breakdown →