MRGPRF-AS1

Across TCGA pan-cancer cohorts, MRGPRF-AS1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of MRGPRF-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MRGPRF-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types MRGPRF-AS1 is over-expressed in tumor, although a few such as KIRC and BLCA show the opposite, repressed pattern.

KIRC, BLCA, and COAD are the cancer types where MRGPRF-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MRGPRF-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−0.210	<.001	12	view →
BLCA	Male	III,IV	−1.015	<.001	11	view →
COAD	Male	II,III,IV	−0.466	<.001	10	view →
LUAD	All	III,IV	−0.215	<.001	9	view →
KICH	Female	All	−0.450	<.001	8	view →
STAD	All	All	−0.579	<.001	7	view →
KIRP	Male	All	−0.298	<.001	7	view →
UCEC	All	All	−1.326	<.001	6	view →
BRCA	Female	II,III,IV	−0.488	<.001	6	view →
LUSC	Female	All	−0.235	<.001	6	view →
READ	All	All	−0.582	.002	3	view →
PRAD	All	All	−0.381	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

MRGPRF-AS1–KIRC

Open the KIRC breakdown →