MRGPRD

Across TCGA patient cohorts, MRGPRD RNA expression is significantly associated with the go_rna of many other GO terms, with 6,977 significant associations in total. STAD shows the largest number of these associations.

The most reproducible MRGPRD-associated GO terms across cancer lineages are Epigenetic regulation of gene expression, Positive regulation of DNA metabolic process, and Regulation of post-translational protein modification. Each is linked with MRGPRD in more than 23 cancer types. Because this analysis shows association rather than direction, both MRGPRD-to-partner and partner-to-MRGPRD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Epigenetic regulation of gene expression grouped by MRGPRD-low versus MRGPRD-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MRGPRD→partner) and Y-score (partner→MRGPRD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Epigenetic regulation of gene expression →	+0.077	+0.323	<.001	.005	2	24
ESCA	Positive regulation of DNA metabolic process →	+0.071	+0.328	<.001	.002	3	22
ESCA	Regulation of post-translational protein modification →	+0.081	+0.422	<.001	.001	3	22
STAD	Negative regulation of supramolecular fiber organization →	+0.059	+0.254	<.001	<.001	3	22
STAD	Vacuole organization →	+0.063	+0.244	<.001	<.001	3	22
ESCA	Peptidyl-lysine modification →	+0.068	+0.323	<.001	.002	3	22

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,977 associations by consensus.

Epigenetic regulation of gene expression by MRGPRD expression — ESCA

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