MRGPRD

Across TCGA cell cohorts, MRGPRD mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MRGPRD-associated genes across cancer lineages are SLC5A8, ASZ1, and DCLK3. Each is linked with MRGPRD in more than 1 cancer types. Because this analysis shows association rather than direction, both MRGPRD-to-partner and partner-to-MRGPRD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC5A8 grouped by MRGPRD-low versus MRGPRD-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRGPRD→partner) and Y-score (partner→MRGPRD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SLC5A8 →	+0.070	+4.906	<.001	.006	3	2
BLOOD_Leukemia	ASZ1 →	+0.120	+4.567	<.001	.001	3	1
BLOOD_Leukemia	DCLK3 →	+0.176	+3.769	.001	.008	3	1
BLOOD_Leukemia	DSG4 →	+0.033	+4.269	<.001	.002	3	1
BLOOD_Leukemia	MAGEE2 →	+0.266	+3.855	<.001	.007	3	1
BLOOD_Leukemia	TAS2R39 →	+0.083	+4.339	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

SLC5A8 by MRGPRD expression — OESOPHAGUS

Explore this box plot interactively →