MRGBP

Across TCGA patient cohorts, MRGBP mutation is significantly associated with the RNA expression of many other genes, with 800 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRGBP-associated genes across cancer lineages are MTND6P17, RNU1-62P, and MTND6P20. Each is linked with MRGBP in more than 1 cancer types. Because this analysis shows association rather than direction, both MRGBP-to-partner and partner-to-MRGBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTND6P17 grouped by MRGBP-low versus MRGBP-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRGBP→partner) and Y-score (partner→MRGBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MTND6P17 →	+0.233	+7.640	<.001	.009	3	2
LUAD	RNU1-62P →	+0.183	+5.315	<.001	.003	3	2
BLCA	MTND6P20 →	+0.104	+7.640	<.001	.009	3	1
BLCA	OR4A7P →	+0.049	+7.640	<.001	.009	3	1
BLCA	OR4K16P →	+0.049	+7.640	<.001	.009	3	1
BLCA	LINC02164 →	+0.153	+7.640	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 800 associations by consensus.

MTND6P17 by MRGBP expression — BLCA

Explore this box plot interactively →