MRGBP

Across TCGA pan-cancer cohorts, MRGBP RNA is linked to patient survival in 30 of 34 cancer types, making it the most broadly survival-associated MRGBP data layer compared with 3 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher MRGBP RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MRGBP expression acts as an unfavorable survival marker, although some lineages such as DLBC and READ show a favorable association.

UVM, KIRP, and MESO are the cancer types where MRGBP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.282	0.774	<.001	120	view →
KIRP	DFS	Median	All	0.855	0.958	<.001	117	view →
MESO	OS	Median	All	0.403	0.676	<.001	108	view →
BLCA	OS	Median	II,III,IV	0.535	0.705	.001	72	view →
LIHC	OS	Median	All	0.605	0.764	<.001	72	view →
ACC	DFS	Median	All	0.247	0.655	<.001	70	view →
KIRC	DFS	Tertile	II,III,IV	0.378	0.618	<.001	63	view →
KICH	DFS	Tertile	III,IV	0.035	1.000	.004	60	view →
LGG	DFS	Median	All	0.625	0.848	<.001	54	view →
LUSC	DFS	Tertile	III,IV	0.364	0.806	<.001	46	view →
UCEC	DFS	Median	All	0.568	0.728	<.001	40	view →
HNSC	DFS	Quartile	All	0.621	0.759	.001	35	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 30 lineages.

MRGBP–UVM (DFS)

Open the UVM breakdown →