MRGBP

Across TCGA patient cohorts, MRGBP mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRGBP-associated genes across cancer lineages are eIF4E, ERK2, and JNK2. Each is linked with MRGBP in more than 1 cancer types. Because this analysis shows association rather than direction, both MRGBP-to-partner and partner-to-MRGBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by MRGBP-low versus MRGBP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRGBP→partner) and Y-score (partner→MRGBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.222	+3.321	.029	.010	3	1
UCEC	ERK2 →	+0.283	+3.169	.002	.019	3	1
UCEC	JNK2 →	+0.325	+3.009	<.001	.019	3	1
UCEC	Ku80 →	+0.227	+2.179	.047	.034	3	1
UCEC	MAPK_pT202_Y204 →	-0.659	-3.321	.003	.010	3	1
UCEC	MEK1 →	+0.432	+3.321	.014	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

eIF4E by MRGBP expression — UCEC

Explore this box plot interactively →