MRGBP

Across TCGA cell cohorts, MRGBP RNA expression is significantly associated with the go_rna of many other GO terms, with 4,345 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MRGBP-associated GO terms across cancer lineages are Regulation of telomeric loop disassembly, Positive regulation of cell cycle checkpoint, and Establishment of mitotic spindle localization. Each is linked with MRGBP in more than 15 cancer types. Because this analysis shows association rather than direction, both MRGBP-to-partner and partner-to-MRGBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of telomeric loop disassembly grouped by MRGBP-low versus MRGBP-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MRGBP→partner) and Y-score (partner→MRGBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of telomeric loop disassembly →	+0.128	+1.062	<.001	<.001	3	16
SKIN	Positive regulation of cell cycle checkpoint →	+0.096	+0.649	<.001	<.001	3	15
SOFT_TISSUE	Establishment of mitotic spindle localization →	+0.102	+0.780	.008	.006	3	15
BONE	Regulation of centriole-centriole cohesion →	+0.212	+0.959	<.001	<.001	3	14
SOFT_TISSUE	Establishment of spindle orientation →	+0.104	+0.820	.002	.004	3	14
SOFT_TISSUE	Establishment of spindle localization →	+0.102	+0.797	.001	.006	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,345 associations by consensus.

Regulation of telomeric loop disassembly by MRGBP expression — SOFT_TISSUE

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