MRGBP

Across TCGA cell cohorts, MRGBP mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MRGBP-associated genes across cancer lineages are HSFY1, LBHD2, and AMELY. Each is linked with MRGBP in more than 1 cancer types. Because this analysis shows association rather than direction, both MRGBP-to-partner and partner-to-MRGBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSFY1 grouped by MRGBP-low versus MRGBP-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRGBP→partner) and Y-score (partner→MRGBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HSFY1 →	+0.019	+4.415	<.001	.007	3	1
LARGE_INTESTINE	LBHD2 →	+0.125	+4.273	<.001	.006	3	1
LARGE_INTESTINE	AMELY →	+0.045	+5.022	<.001	.002	3	1
CNS	GPR149 →	+0.022	+5.321	<.001	.005	3	1
CNS	KCNK16 →	+0.151	+4.981	<.001	.008	3	1
BLOOD_Leukemia	APOL5 →	+0.015	+5.060	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

HSFY1 by MRGBP expression — LARGE_INTESTINE

Explore this box plot interactively →