MRE11

Across TCGA patient cohorts, MRE11 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRE11-associated genes across cancer lineages are eIF4E, Gab2, and mTOR_pS2448. Each is linked with MRE11 in more than 2 cancer types. Because this analysis shows association rather than direction, both MRE11-to-partner and partner-to-MRE11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by MRE11-low versus MRE11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRE11→partner) and Y-score (partner→MRE11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.188	+2.201	.007	<.001	2	3
UCEC	Gab2 →	+0.286	+1.700	.016	.042	3	2
UCEC	mTOR_pS2448 →	-0.104	-2.209	.036	.009	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.390	-1.678	.009	.021	3	2
UCEC	Caspase-7-cleavedD198 →	+0.591	+2.827	.002	.001	3	2
UCEC	4E-BP1 →	+0.332	+2.936	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

eIF4E by MRE11 expression — UCEC

Explore this box plot interactively →