MRE11

Across TCGA pan-cancer cohorts, MRE11 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated MRE11 data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher MRE11 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MRE11 expression acts as an unfavorable survival marker, although some lineages such as READ and UCS show a favorable association.

ACC, READ, and LIHC are the cancer types where MRE11 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.398	0.754	<.001	82	view →
READ	OS	Quartile	All	1.000	0.531	<.001	60	view →
LIHC	OS	Median	All	0.714	0.836	<.001	59	view →
UCS	OS	Median	IV	0.817	0.302	.002	56	view →
KIRC	DFS	Median	All	0.935	0.791	<.001	34	view →
LGG	OS	Tertile	All	0.722	0.877	<.001	33	view →
PAAD	OS	Quartile	All	0.494	0.794	.011	28	view →
KIRP	DFS	Tertile	All	0.803	0.923	.007	20	view →
UVM	OS	Median	III,IV	0.296	1.000	.005	20	view →
BRCA	OS	Tertile	II,III,IV	0.485	0.669	.003	20	view →
HNSC	OS	Tertile	All	0.817	0.693	.010	19	view →
THYM	OS	Quartile	All	1.000	0.646	.010	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

MRE11–ACC (DFS)

Open the ACC breakdown →