MRE11

Across TCGA cell cohorts, MRE11 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,999 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible MRE11-associated GO terms across cancer lineages are DNA strand elongation, Regulation of mitotic metaphase/anaphase transition, and Centrosome cycle. Each is linked with MRE11 in more than 19 cancer types. Because this analysis shows association rather than direction, both MRE11-to-partner and partner-to-MRE11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA strand elongation grouped by MRE11-low versus MRE11-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MRE11→partner) and Y-score (partner→MRE11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA strand elongation →	+0.178	+0.740	.003	.001	3	20
PANCREAS	Regulation of mitotic metaphase/anaphase transition →	+0.097	+0.637	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Centrosome cycle →	+0.088	+1.267	<.001	.001	3	18
CNS	Protein localization to kinetochore →	+0.154	+0.669	<.001	<.001	3	18
LUNG_NSCLC_LUSC	Negative regulation of mitotic nuclear division →	+0.153	+0.909	.008	.001	2	19
BREAST	Negative regulation of nuclear division →	+0.118	+0.840	<.001	.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,999 associations by consensus.

DNA strand elongation by MRE11 expression — BONE

Explore this box plot interactively →