MRE11

Across TCGA cell cohorts, MRE11 mutation is significantly associated with the RNA expression of many other genes, with 144 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MRE11-associated genes across cancer lineages are XAGE5, OR6N1, and MEIKIN. Each is linked with MRE11 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRE11-to-partner and partner-to-MRE11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XAGE5 grouped by MRE11-low versus MRE11-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRE11→partner) and Y-score (partner→MRE11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	XAGE5 →	+0.353	+5.087	<.001	.004	3	1
URINARY_TRACT	OR6N1 →	+0.013	+5.087	<.001	.004	3	1
URINARY_TRACT	MEIKIN →	+0.476	+5.087	<.001	.004	3	1
URINARY_TRACT	OR8K3 →	+0.033	+5.087	<.001	.004	3	1
LUNG_NSCLC_LUSC	TMEM114 →	+0.096	+4.643	<.001	.008	3	1
OVARY	DEFB125 →	+0.146	+4.222	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 144 associations by consensus.

XAGE5 by MRE11 expression — URINARY_TRACT

Explore this box plot interactively →