MRC2

Across TCGA patient cohorts, MRC2 mutation is significantly associated with the RNA expression of many other genes, with 4,113 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRC2-associated genes across cancer lineages are NDUFV2, HMGB1P25, and CCDC58. Each is linked with MRC2 in more than 3 cancer types. Because this analysis shows association rather than direction, both MRC2-to-partner and partner-to-MRC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFV2 grouped by MRC2-low versus MRC2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRC2→partner) and Y-score (partner→MRC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	NDUFV2 →	+0.288	+2.294	.003	.001	3	4
LUAD	HMGB1P25 →	+0.268	+3.473	<.001	<.001	3	4
LUAD	CCDC58 →	+0.583	+2.596	<.001	.006	3	4
LUAD	RN7SL255P →	+0.416	+2.452	<.001	.001	3	4
UCEC	MND1 →	+0.578	+2.191	<.001	<.001	3	4
UCEC	IER3IP1 →	+0.312	+1.556	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,113 associations by consensus.

NDUFV2 by MRC2 expression — SKCM

Explore this box plot interactively →