MRAS

Across TCGA patient cohorts, MRAS mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRAS-associated genes across cancer lineages are eEF2, EGFR_pY1068, and A-Raf_pS299. Each is linked with MRAS in more than 1 cancer types. Because this analysis shows association rather than direction, both MRAS-to-partner and partner-to-MRAS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by MRAS-low versus MRAS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRAS→partner) and Y-score (partner→MRAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.361	+2.999	.014	.035	3	1
UCEC	EGFR_pY1068 →	-0.303	-3.000	.003	.001	3	1
UCEC	A-Raf_pS299 →	-0.144	-3.459	.003	.005	3	1
UCEC	FOXO3a_pS318_S321 →	-0.132	-2.212	.010	.010	3	1
UCEC	GATA6 →	-0.147	-3.155	.021	.018	3	1
UCEC	ACC1 →	+0.473	+3.183	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

eEF2 by MRAS expression — UCEC

Explore this box plot interactively →