MRAS

Across TCGA cell cohorts, MRAS mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible MRAS-associated genes across cancer lineages are PNLIPRP1 and SCGB1D4. Each is linked with MRAS in more than 1 cancer types. Because this analysis shows association rather than direction, both MRAS-to-partner and partner-to-MRAS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PNLIPRP1 grouped by MRAS-low versus MRAS-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRAS→partner) and Y-score (partner→MRAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PNLIPRP1 →	+0.031	+4.450	<.001	.004	3	1
OVARY	SCGB1D4 →	+0.097	+4.807	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

PNLIPRP1 by MRAS expression — OVARY

Explore this box plot interactively →