MPZ

Across TCGA patient cohorts, MPZ protein abundance is significantly associated with the RNA expression of many other genes, with 2,222 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible MPZ-associated genes across cancer lineages are CASQ2, F13A1, and LYVE1. Each is linked with MPZ in more than 2 cancer types. Because this analysis shows association rather than direction, both MPZ-to-partner and partner-to-MPZ results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MPZ versus CASQ2 in HNSC, with a Pearson correlation of 0.51.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPZ→partner) and Y-score (partner→MPZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CASQ2 →	+1.893	+1.098	<.001	<.001	3	3
OV	F13A1 →	+1.367	+1.272	<.001	.001	3	3
HNSC	LYVE1 →	+0.725	+0.916	.002	<.001	3	3
LUAD	CR1 →	+0.994	+1.377	.001	.006	3	3
HNSC	ASB2 →	+0.727	+1.217	.006	.003	3	2
HNSC	SHD →	+0.680	+1.965	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,222 associations by consensus.

MPZ vs CASQ2 — HNSC

Explore this scatter interactively →