MPZ

Across TCGA pan-cancer cohorts, MPZ RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of MPZ’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where MPZ RNA is repressed in tumor relative to normal tissue. In most cancer types MPZ is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.

BLCA, COAD, and KICH are the cancer types where MPZ tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MPZ RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	IV	−2.395	<.001	12	view →
COAD	Male	III,IV	−1.848	<.001	11	view →
KICH	Male	All	−1.384	<.001	10	view →
READ	All	All	−2.458	<.001	7	view →
LIHC	Male	All	+1.818	<.001	7	view →
BRCA	All	III,IV	−1.551	<.001	6	view →
HNSC	Male	All	−1.332	<.001	6	view →
UCEC	All	All	−1.124	<.001	6	view →
STAD	All	All	−1.294	<.001	5	view →
CHOL	All	All	+1.042	.001	4	view →
KIRP	Male	All	−0.596	<.001	3	view →
PRAD	All	All	−1.433	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

MPZ–BLCA

Open the BLCA breakdown →