MPZ

Across TCGA patient cohorts, MPZ mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MPZ-associated genes across cancer lineages are EGFR_pY1068, ACC1, and JNK2. Each is linked with MPZ in more than 1 cancer types. Because this analysis shows association rather than direction, both MPZ-to-partner and partner-to-MPZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by MPZ-low versus MPZ-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPZ→partner) and Y-score (partner→MPZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.294	-2.459	.015	.020	3	1
UCEC	ACC1 →	+0.407	+2.820	.020	.035	3	1
UCEC	JNK2 →	+0.236	+2.834	.014	.034	3	1
UCEC	Myosin-IIa →	-0.178	-2.989	.047	.035	3	1
UCEC	p62 Lck ligand →	+0.398	+2.459	.011	.020	3	1
UCEC	PDCD4 →	-0.633	-2.459	.005	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

EGFR_pY1068 by MPZ expression — UCEC

Explore this box plot interactively →