MPZ

Across TCGA cell cohorts, MPZ mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MPZ-associated genes across cancer lineages are OR4F4, ADIG, and IFNA4. Each is linked with MPZ in more than 1 cancer types. Because this analysis shows association rather than direction, both MPZ-to-partner and partner-to-MPZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4F4 grouped by MPZ-low versus MPZ-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MPZ→partner) and Y-score (partner→MPZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR4F4 →	+0.025	+4.273	<.001	.006	3	1
BLOOD_Leukemia	ADIG →	+0.030	+6.569	<.001	<.001	3	1
BLOOD_Leukemia	IFNA4 →	+0.058	+4.922	<.001	.009	3	1
BLOOD_Leukemia	MT1HL1 →	+0.237	+4.922	.006	.009	3	1
BLOOD_Leukemia	OR10G4 →	+0.021	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

OR4F4 by MPZ expression — LARGE_INTESTINE

Explore this box plot interactively →